The Glycosylphosphatidylinositol biosynthesis pathway in human diseases
نویسندگان
چکیده
منابع مشابه
Biosynthesis and deficiencies of glycosylphosphatidylinositol
At least 150 different human proteins are anchored to the outer leaflet of the plasma membrane via glycosylphosphatidylinositol (GPI). GPI preassembled in the endoplasmic reticulum is attached to the protein's carboxyl-terminus as a post-translational modification by GPI transamidase. Twenty-two PIG (for Phosphatidyl Inositol Glycan) genes are involved in the biosynthesis and protein-attachment...
متن کاملBiosynthesis of glycosylphosphatidylinositol membrane anchors.
Covalent modification of proteins with phosphatidylinositol (PI) was first suggested as a novel mechanism of membrane attachment when it was found that PI-specific phospholipase C (PI-PLC) could release alkaline phosphatase from tissue slices [1-5]. Subsequent compositional analysis of Trypanosoma brucei variant surface glycoprotein (VSG) [6,7], Torpedo acetylcholinesterase [8], erythrocyte ace...
متن کاملnew angle of view on the role of rho/rho kinase pathway in human diseases.
rho-kinase is an effector molecule of rhoa, a monomeric gtp-binding protein, and causes ca2+ sensitization through inactivation of myosin phosphatase. the major physiological functions of rho/rho-kinase cascade include contraction, proliferation and migration in cells.there are some excellent reviews about rho/rho-kinase signal pathway, most of which focus on the specific proteins of the pathwa...
متن کاملInhibition of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana by mannosamine.
In several Leishmania species, glycosylated inositol phospholipids exist as free lipids, as membrane protein anchors, and as the membrane-binding moieties of the lipophosphoglycans. Both the glycolipid-anchored cell surface metalloproteinase, gp63, and the lipophosphoglycans have been proposed to be involved in cell invasion. Moreover, the lipophosphoglycans have been implicated in the survival...
متن کاملHuman and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants.
Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins. The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP to phosphatidylinositol (PI). The products of three mammalian genes, PIG-A, PIG-C and PIG-H, have previously been shown to be involved in the putative enzymic complex. Here we report the cloning of human...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Orphanet Journal of Rare Diseases
سال: 2020
ISSN: 1750-1172
DOI: 10.1186/s13023-020-01401-z